The Potential Effects of Quercetin-Loaded Nanoliposomes on Amoxicillin/Clavulanate-Induced Hepatic Damage: Targeting the SIRT1/Nrf2/NF-κB Signaling Pathway and Microbiota Modulation
نویسندگان
چکیده
Amoxicillin/clavulanate (Co-Amox), a commonly used antibiotic for the treatment of bacterial infections, has been associated with drug-induced liver damage. Quercetin (QR), naturally occurring flavonoid pleiotropic biological activities, poor water solubility and low bioavailability. The objective this work was to produce more bioavailable formulation QR (liposomes) determine effect its intraperitoneal pretreatment on amelioration Co-Amox-induced damage in male rats. Four groups rats were defined: control, liposomes (QR-lipo), Co-Amox, Co-Amox QR-lipo. Liver injury severity evaluated all through measurement serum enzymes, antioxidant status, proinflammatory mediators, microbiota modulation. results revealed that QR-lipo reduced hepatic rats, as indicated by reduction enzymes total capacity. In addition, upregulated transcription factors SIRT1 Nrf2 downregulated signatures, including IL-6, IL-1β, TNF-α, NF-κB, iNOS, upregulation anti-inflammatory one, IL10. also prevented gut dysbiosis favoring colonization Lactobacillus, Bifidobacterium, Bacteroides over Clostridium Enterobacteriaceae. These suggested ameliorates targeting SIRT1/Nrf2/NF-κB modulating microbiota.
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ژورنال
عنوان ژورنال: Antioxidants
سال: 2023
ISSN: ['2076-3921']
DOI: https://doi.org/10.3390/antiox12081487